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Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness

By   /  June 10, 2021  /  Comments Off on Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness

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INTRODUCTION

The cognitive and behavioral effects of striatal dopamine signaling are related to its influence on large-scale neural activity. Recent work in rodents has begun to characterize the nature of the relationship between local striatal signaling and cortex-wide effects (13). Striatal dopamine release, secondary to optogenetic or chemogenetic activation of mesolimbic pathways (2, 3) or hypothalamic self-stimulation (1), has been shown to affect cortical activity, as has selective overexpression of striatal D2 receptors (4). This correspondence between striatal dopamine and cortical activity is of relevance, given the frequent simultaneous disruption of striatal dopaminergic function and cortical function in neuropsychiatric…



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