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What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes

By   /  June 10, 2021  /  Comments Off on What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes

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Abstract

The organs and metabolic pathways involved in energy metabolism, and the process of ATP production from nutrients, are comparable between humans and Drosophila melanogaster. This level of conservation, together with the power of Drosophila genetics, makes the fly a very useful model system to study energy homeostasis. Here, we discuss the major organs involved in energy metabolism in Drosophila and how they metabolize different dietary nutrients to generate adenosine triphosphate. Energy metabolism in these organs is controlled by cell-intrinsic, paracrine, and endocrine signals that are similar between Drosophila and mammals. We describe how these signaling pathways are regulated by several physiological and environmental cues…



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